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Adverse reaction and Precautions of Sodium Fusidate:
1. Adverse reactions were mild and slight, and there were slight gastrointestinal reactions in the oral administration. Intravenous injection of product can lead to thrombophlebitis and venous spasm.Daily use of 1.5 to 3 grams of reversible would increase aminotransferase according to some reports.
2. There have been reports of individual patients after treatment may appear retrograde jaundice, which is mainly seen in the high-dose intravenous administration, especially in patients with severe S. aureus bacteremia. If persistent jaundice, you should stop using the drug to make the serum bilirubin return to normal. Allergic reactions were rarely reported.
3. Since the metabolism and excretion properties of fusidic sodium, when long-term large doses of medication or in combination with other fusidic sodium discharge pathway similar drugs (such as clindamycin or rifampicin), liver dysfunction and biliary abnormalities patients should regularly check liver function.
4. In in vitro experiments, fusidic sodium may be substituted on the bilirubin albumin binding sites, such substitution clinical significance is unclear. It also did not discover the nuclear jaundices after using this product, but the premature children, jaundice, acidosis and severe sick newborns should pay attention to this factor when using this product.
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